The body produces melatonin naturally, and a new study with the zebra fish suggests that even in the absence of a supplement, natural melatonin can help you fall and stay asleep.
There are several factors at stake when you are starting to feel tired.
Sleep is believed to be regulated by two mechanisms: a homeostatic mechanism, which responds to internal stimuli of the body for sleep, and a circadian mechanism that responds to external signals, such as darkness and light, signalling moments appropriate for the sleep and wakefulness where melatonin intervenes.
For years, researchers have known that melatonin production is regulated by the circadian clock, and that it produces more of the hormone at night than it does during the day. However, this fact alone is not enough to show that melatonin promotes sleep.
For example, although nocturnal animals sleep during the day and are active during the night, they also produce most of the melatonin at night.
Melatonin usually plays an important role in sleep and is needed both to sleep and to stay asleep. In humans and zebra fish, melatonin is produced in a part of the brain called the pineal gland.
To confirm that the mutation-induced reduction in sleep was due to the lack of melatonin, researchers used a drug to specifically destroy the pineal gland cells, thus stopping the production of the hormone Melatonin and verify the most relevant data.
Sleep patterns, like many other biological and behavioural processes, are known to be regulated by the circadian clock. In one organism, the circadian clock aligns these processes with daily changes in the environment, such as daylight and the darkness of the night.
However, while a large part is known about how the circadian clock works, it was not known how the clock regulates sleep.
Because the researchers had determined that melatonin is involved in the promotion of natural sleep, this study was conducted because they wondered whether melatonin intervenes in the circadian regulation of sleep.
For years, people have been looking at rodents for a factor that is required for circadian sleep regulation and have found some other candidate molecules that, like melatonin, are regulated by the circadian clock and can induce sleep when It is administered in the form of supplements.
However, other organisms lacking these factors had normal circadian sleep cycles.
Maybe all the molecules work together, and in this study, we found that removing a molecule, melatonin, is the whole show.
It is one of those rare and surprisingly clear results for a deeper analysis of the effects of melatonin on the body and on sleep cycles.
After finding that melatonin is necessary for circadian sleep regulation, researchers and their colleagues observed a neuromodulator called adenosine as part of the homeostatic mechanism that promotes sleep.
As an animal consumes energy throughout the day, adenosine accumulates in the brain that causes the animal to feel more and more tired, a pressure that is relieved by sleep and thus melatonin comes into action helping to regulate the biological cycle for scan of the body.
Reading late at night, watching TV, or sending emails in the early hours of the morning may be disrupting your melatonin production and depriving you of many health benefits of this hormone.
When you take melatonin it is important for the proper functioning of your immune system, free radicals, sömntabletter receptfria, reducing inflammation, and helps your body to get rid of cancer cells; Several studies point to the role of melatonin in protecting you from various types of cancer, including breast cancer.
Even the slightest amount of light in the white or blue bandwidths is enough to seriously depress the production of your pineal gland melatonin at night, so sleeping in total darkness is so important.
Suggestions are given for optimizing their production of melatonin, such as a type of light that does not interrupt their production of melatonin.
Light pollution is a growing problem that has adverse biological effects on plants and animals, especially birds whose reproductive and migratory patterns are disturbed.